Projects

Our group develops software and tools in different areas. Below we provide links to different resources. Most of our code is freely accessible and open source. If not specificially stated, we apply a MIT License, i.e. our software is provided as is and without warranties of any kind:

hemoMIPs - targeted sequencing analysis and result reporting pipeline

CADD scripts - scores the deleteriousness of single nucleotide variants and insertion/deletions in the human genome

CADD webserver - data access and download of CADD scores

Saturation Mutagenesis - MPRA visualization of 20 regulatory elements and one ultra conserverd element

MPRAflow (+documentation) - Pipeline to processes sequencing data from Massively Parallel Reporter Assays (MPRAs).

ReMM Score - The Regulatory Mendelian Mutation (ReMM) score was created for relevance prediction of non-coding variations (SNVs and small InDels) in the human genome (hg19) in terms of Mendelian diseases.

CADD-SV - CADD-SV is a framework to estimate the impact of Structural Variants in the human genome. We combine various annotations to predict the deleteriousness of human deletions.

Cell-free DNA - analysis of epigenetic signals captured by fragmentation patterns of cell-free DNA.

Cell-free DNA workflows - Workflows for analysing epigenetic signals captured by fragmentation patterns of cell-free DNA.

IBIS - accurate, fast and easy-to-use base caller for the Illumina sequencing system

freeIBIS - accurate, fast and easy-to-use base caller for the Illumina sequencing system

index design - index design and analysis software for highly multiplexed target capture and sequencing.